Inhibition of in vitro proliferative response of cultured t lymphocytes to interleukin-2 by gold sodium thiomalate
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چکیده
منابع مشابه
Inhibition of IL-13 by Antisense Oligonucleotide Changes Immunoglobulin Isotype Profile in Cultured B-Lymphocytes
The link between IL-13 and bronchial hyper-responsiveness has brought this cytokine as a potential therapeutic target for asthma and allergic diseases. At the present study, we address the role of B cell derived IL-13 in the IgE and other immunoglobulin development. Antisense oligo for human IL-13 m-RNA was used to study IgE down regulation. Human B-lymphocytes were purified by positive selecti...
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To confirm the side-effects of gold sodium thiomalate (GSTM), we carried out a retrospective study examining 102 consecutive patients with rheumatoid arthritis attending the Rheumatology Unit of Hafez Hospital, Shiraz, Iran, in whom GSTM was initiated between 1983-1989. Only patients with classical or definite RA (ARA criteria) we(e included in this study. Patients were categorized as havi...
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To the Editor: In their interesting paper, Sfikakis et a1 state " no previous study, to our knowledge, has investigated the in vitro effects of gold compounds on the IL-2/IL-2R [interleukin-2/interleukin-2 receptor] system " (1). This is an oversight, since my colleagues and I have previously shown an in vitro effect of gold sodium thiomalate (GST) on the IL-2/IL-2R system (2). In our experimen...
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to determine the complications of gold sodium thiomalate therapy in rheumatoid arthritis (ra), 32 patients with active ra (27 female, 5 male) treated for a mean period of 28 ? 14 weeks were studied. from these patients, 62.5 (46-79) percent showed at least one drug reaction. pruritus was the most common complication occurred in 59 (42-76) percents, and was accompanied by skin rush in 37 (15-57)...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1988
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780310204